Airway complication associated with injection of phosphatidylcholine and deoxycholic acid into the neck: a case report

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Sanith Cheriyan
Jacob Jervis-Bardy


phosphatidylcholines, deoxycholic acid, adipose tissue


The practice of delivering cosmetic injectables in the outpatient setting continues to grow in Australia.1 The increase in demand has seen a dramatic rise in the number of new cosmetic injectable clinics using telehealth prescribing services. Lipodissolve treatment is an example of a non-surgical procedure that aims to improve the appearance of a ‘double chin’ by injection of phosphatidylcholine (PC) and deoxycholic acid (DCA) into submental adipose tissue. We describe a case of an airway complication and hospitalisation secondary to the injection of Lipodissolve in the neck of a 23-year-old female.

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1. Medical Board of Australia. Public consultation paper and regulation impact statement–registered medical practitioners who provide medical and surgical procedures [web report]. Canberra, AHPRA [cited 29 May 2015]. Available from:
2. Department of Health, Therapeutic Goods Administration. Australian public assessment report for deoxycholic acid [web report]. Canberra: Australian Government [April 2017; cited 12 September 2019] Available from:
3. Bechara FG, Sand M, Hoffmann K, Sand D, Altmeyer P, Stucker M. Fat tissue after lipolysis of lipomas: a histopathological and immunohistochemical study. J Cutan Pathol. 2007;34(7):552–57. PMid:17576334
4. Department of Health, Therapeutic Goods Administration. Public summary for ARTG entry: 312536 – liposomal phosphatidyl choline [web report]. Canberra: Australian Government [2018; cited 12 September 2019]. Available from:
5. Banerjee P, Joo JB, Buse JT, Dawson G. Differential solubilization of lipids along with membrane proteins by different classes of detergents. Chem Phys Lipids. 1995;77(1):65–78.
6. Almgren M. Mixed micelles and other structures in the solubilization of bilayer lipid membranes by surfactants. Biochim Biophys Acta. 2000;1508(1–2):146–63.
7. Salles AG, Valler CS, Ferreira MC. Histologic response to injected phosphatidylcholine in fat tissue: experimental study in a new rabbit model. Aesthetic Plast Surg. 2006;30(4):479–84; discussion 85. PMid:16855889
8. Walker PS, Lee DR, Toth BA, Bowen B. Histological analysis of the effect of ATX-101 (deoxycholic acid injection) on subcutaneous fat: results from a phase 1 open-label study. Dermatol Surg. 2020;46(1):70–77. PMid:30883481
9. Bhatti Z, Virk J, Sivalingam D. Submental abscess after deoxycholic acid injection. Am J Ther. 2018;25(2):e285–e6. PMid:28166163
10. Falcetta S, Cavallo S, Gabbanelli V, Pelaia P, Sorbello M, Zdravkovic I, Donati A. Evaluation of two neck ultrasound measurements as predictors of difficult direct laryngoscopy: a prospective observational study. Eur J Anaestheiol. 2018;35(8):605–12. PMid:29889671