Airway complication associated with injection of phosphatidylcholine and deoxycholic acid into the neck: a case report
Main Article Content
Keywords
phosphatidylcholines, deoxycholic acid, adipose tissue
Abstract
The practice of delivering cosmetic injectables in the outpatient setting continues to grow in Australia.1 The increase in demand has seen a dramatic rise in the number of new cosmetic injectable clinics using telehealth prescribing services. Lipodissolve treatment is an example of a non-surgical procedure that aims to improve the appearance of a ‘double chin’ by injection of phosphatidylcholine (PC) and deoxycholic acid (DCA) into submental adipose tissue. We describe a case of an airway complication and hospitalisation secondary to the injection of Lipodissolve in the neck of a 23-year-old female.
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References
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9. Bhatti Z, Virk J, Sivalingam D. Submental abscess after deoxycholic acid injection. Am J Ther. 2018;25(2):e285–e6. https://doi.org/10.1097/MJT.0000000000000514 PMid:28166163
10. Falcetta S, Cavallo S, Gabbanelli V, Pelaia P, Sorbello M, Zdravkovic I, Donati A. Evaluation of two neck ultrasound measurements as predictors of difficult direct laryngoscopy: a prospective observational study. Eur J Anaestheiol. 2018;35(8):605–12. https://doi.org/10.1097/EJA.0000000000000832 PMid:29889671
2. Department of Health, Therapeutic Goods Administration. Australian public assessment report for deoxycholic acid [web report]. Canberra: Australian Government [April 2017; cited 12 September 2019] Available from: https://www.tga.gov.au/sites/default/files/auspar-deoxycholic-acid-170406.pdf
3. Bechara FG, Sand M, Hoffmann K, Sand D, Altmeyer P, Stucker M. Fat tissue after lipolysis of lipomas: a histopathological and immunohistochemical study. J Cutan Pathol. 2007;34(7):552–57. https://doi.org/10.1111/j.1600-0560.2006.00651.x PMid:17576334
4. Department of Health, Therapeutic Goods Administration. Public summary for ARTG entry: 312536 – liposomal phosphatidyl choline [web report]. Canberra: Australian Government [2018; cited 12 September 2019]. Available from: https://www.ebs.tga.gov.au/servlet/xmlmillr6?dbid=ebs/PublicHTML/pdfStore.nsf&docid=2DF8E619578E1122CA258363003CC611&agid=(PrintDetailsPublic)&actionid=1
5. Banerjee P, Joo JB, Buse JT, Dawson G. Differential solubilization of lipids along with membrane proteins by different classes of detergents. Chem Phys Lipids. 1995;77(1):65–78. https://doi.org/10.1016/0009-3084(95)02455-R
6. Almgren M. Mixed micelles and other structures in the solubilization of bilayer lipid membranes by surfactants. Biochim Biophys Acta. 2000;1508(1–2):146–63. https://doi.org/10.1016/S0005-2736(00)00309-6
7. Salles AG, Valler CS, Ferreira MC. Histologic response to injected phosphatidylcholine in fat tissue: experimental study in a new rabbit model. Aesthetic Plast Surg. 2006;30(4):479–84; discussion 85. https://doi.org/10.1007/s00266-005-0210-1 PMid:16855889
8. Walker PS, Lee DR, Toth BA, Bowen B. Histological analysis of the effect of ATX-101 (deoxycholic acid injection) on subcutaneous fat: results from a phase 1 open-label study. Dermatol Surg. 2020;46(1):70–77. https://doi.org/10.1097/DSS.0000000000001851 PMid:30883481
9. Bhatti Z, Virk J, Sivalingam D. Submental abscess after deoxycholic acid injection. Am J Ther. 2018;25(2):e285–e6. https://doi.org/10.1097/MJT.0000000000000514 PMid:28166163
10. Falcetta S, Cavallo S, Gabbanelli V, Pelaia P, Sorbello M, Zdravkovic I, Donati A. Evaluation of two neck ultrasound measurements as predictors of difficult direct laryngoscopy: a prospective observational study. Eur J Anaestheiol. 2018;35(8):605–12. https://doi.org/10.1097/EJA.0000000000000832 PMid:29889671