Biodegradable temporising matrix in severe meningococcal septicaemia: a case report

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Matthew Jennings
Jake Willet
Patrick Coghlan
Nicholas S Solanki
John E Greenwood


soft tissue injuries, meningococcal infections, artificial skin


Expanding experience with NovoSorb Biodegradable Temporising Matrix™ (BTM, PolyNovo Biomaterials Pty Ltd, Port Melbourne, Victoria, Australia) for complex wounds encouraged its use in the following case, which required reconstruction of extensive soft-tissue defects with exposed bone resulting from the sequelae of meningococcal B infection with septic shock and disseminated intravascular coagulation.

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1. Sadarangani M, Scheifele D, Halperin S, Vaudry W, Le Saux, N, Tsang R, Bettinger J. Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study. Clin Infect Dis. 2015;60(8):27–35. PMid:25605282
2. Buysse C, Oranje A, Zuidema E, Hazelzet J, Hop W, Diepstraten A, Joosten K. Long-term skin scarring and orthopaedic sequelae in survivors of meningococcal septic shock. Arch Dis Child Educ Pract Ed. 2009;94(5):381–86. PMid:19147623
3. Cartwright K, Stuart J, Jones D, Noah N. The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica. Epidemiol Infect. 1987;99(3):591-601. PMid:3123263 PMCid:PMC2249239
4. Adcock D, Hicks M. Dermatopathology of skin necrosis associated with purpura fulminans. Semin Thromb Hemost. 1990;16(4):283–92 PMid:2281318
5. Greenwood J, Schmitt E, Wagstaff M. Experience with a synthetic bilayer biodegradable temporising matrix in significant burn injury. Burns Open. 2018;2(1):17–34.
6. Wagstaff M, Salna I, Caplash Y, Greenwood J. Biodegradable temporising matrix (BTM) for the reconstruction of defects following serial debridement for necrotising fasciitis: a case series. Burns Open. 2019;3(1):12–30.
7. Damkat-Thomas L, Greenwood J, Wagstaff M. A synthetic biodegradable temporising matrix in degloving lower extremity trauma reconstruction. Plast Reconstr Surg Glob Open. 2019;7(4):e2110. PMid:31321161 PMCid:PMC6554176
8. Greenwood J. The evolution of acute burn care: retiring the split skin graft. Ann R Coll Surg Engl. 2017;99(6):432–38. PMid:28560888 PMCid:PMC5696993
9. Greenwood J, Dearman B. Comparison of a sealed, polymer foam biodegradable temporizing matrix against Integra® dermal regeneration template in a porcine wound model. J Burn Care Res. 2012;33(1):163–73. PMid:22002205
10. Greenwood J, Wagstaff M, Rooke M, Caplash Y. Reconstruction of extensive calvarial exposure after major burn injury in 2 stages using a biodegradable polyurethane matrix. Eplasty. 2016;16:e17